Browsing by Subject "breast cancer"
Now showing items 1-18 of 18
-
(2013-08-12)Breast cancer is the leading cause of cancer death among women worldwide and polyphenols are under investigation as an alternative to conventional treatment approaches of breast cancer. The anti-inflammatory and ...
-
(2020-04-13)Tissue engineered 3D cell culture models have shown promise investigating the influence of the tumor microenvironment on cancer cell behavior. Synthetic hydrogels, such as those made from poly(ethylene glycol) (PEG), can ...
-
(2009-05-15)Estrogen receptor α (ERα) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ERα. The compounds investigated in this study include 17β-estradiol (E2), ...
-
(2020-06-01)IGF-1 has been implicated in breast cancer due to its mitogenic and anti-apoptotic effects. Previous studies with the BK5.IGF-1 transgenic (Tg) mouse model reveal that IGF-1 does not act as a classical, post-carcinogen ...
-
(2012-06-08)Breast cancer is the most common cancer in women and is predominantly estrogen dependent [1]. About 1 in 8 women in the United States (12%) will develop invasive breast cancer over the course of her lifetime. Failure in ...
-
(Texas A&M University, 2004-09-30)Sequence-specific small interfering RNA (siRNA) duplexes can be used for gene silencing in mammalian cells and as mechanistic probes for determining gene function. Transfection of siRNA for specificity protein 1 (Sp1) in ...
-
(2014-12-11)Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, ...
-
(2020-04-30)Normal physiological or developmental processes, including invasion, proliferation, metabolic reprogramming, and apoptotic escape, are often hijacked in malignant states to drive disease occurrence or progression. As ...
-
(2009-05-15)One in 8 women will be diagnosed with breast cancer in the United States and estrogen receptor (ER) status largely influences the type and subsequent success of treatment employed. Although ER-positive breast cancer can ...
-
(Texas A&M University, 2008-10-10)MicroRNAs (miRNAs) play a vital role in differentiation, proliferation and tumorigenesis by binding to messenger RNAs (mRNA) and inhibiting translation. To initiate an investigation into the identification of miRNAs in the ...
-
(Texas A&M University, 2004-11-15)Photoacoustic computed tomography (PAT) has great potential for application in the biomedical field. It best combines the high contrast of electromagnetic absorption and the high resolution of ultrasonic waves in biological ...
-
(2016-08-01)More than 25% of all newly diagnosed breast cancer cases are ductal carcinoma in situ (DCIS), the most commonly diagnosed form of non-invasive breast cancer. This incidence coupled with the detrimental side effects associate ...
-
(2023-03-16)The incidence of breast cancer is the number one cause of cancer in women globally. Due to the complex heterogeneous diversity of this disease, certain classifications of breast cancer have developed targeted therapeutic ...
-
(2009-05-15)Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation and activation of kinase pathways in MCF-7 breast cancer cells. The role of estrogen receptor α (ERα) in mediating responses induced ...
-
(2015-07-15)The high incidence of invasive breast carcinomas, which accounts for about 90% of all breast cancer-related deaths, underscores the need for new and more effective therapeutic approaches to block the development of the ...
-
(2009-05-15)Single minded 2 (Sim2) is a member of the basic helix-loop-helix Per-ARNT-Sim (Period-Arylhydrocarbon Nuclear Translocator-Single minded) family. Human SIM2 is involved in the etiology of the Down’s phenotype. In addition ...
-
(2016-05-10)This dissertation used multilevel regression methods to explore rural-urban disparities in stage at diagnosis of, and treatment of early-stage breast cancer among women diagnosed between 1995 and 2012, and whether other ...